What are the long-term effects of taking sulfasalazine? Long-term side effects with sulfasalazine may include serious allergic reactions, low blood cell counts, infections, heart, liver and kidney damage, nerve or muscle problems, low sperm count, sun sensitivity and severe skin reactions.
Patients should be informed of the possibility of adverse reactions and of the need for careful medical supervision. The occurrence of sore throat, fever, pallor, purpura, or jaundice may indicate a serious blood disorder. Should any of these occur, the patient should seek medical advice.
Sulfasalazine is of proven therapeutic v;iIuc in chronic inflammatory l>owcl diseases (ulcerative colitis and Crohn's diseasc in the colon) of mild and moderate degrees. However, owing to adverse effects (allergy. dyspepsia), this drug often has to be withdrawn. The present work analyzes.
You can usually eat and drink normally while taking sulfasalazine. If you have indigestion or feel sick, it's best to stick to simple meals, and avoid alcohol and spicy foods. For inflammatory bowel disease, your doctor may advise you make some changes to your diet as part of your treatment.
Discussion: Three-week sulfasalazine syndrome is a rare drug-induced hypersensitivity reaction characterized by a pentad of fever, lymphadenopathy, dermatitis, hematological abnormalities, and hepatitis around the third week of treatment.
If you have any of the following symptoms, stop taking sulfasalazine and call your doctor immediately: rash, hives, itching or peeling or blistering skin. swelling of the eyes, face, lips, tongue, mouth, or throat. difficulty breathing or swallowing.
For most people, methotrexate is the first-choice treatment for rheumatoid arthritis, according to the American College of Rheumatology. That's because it's affordable, effective for many, and safe.
Interactions between your drugs
No interactions were found between sulfasalazine and Vitamin D3. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Though sulfasalazine may cause increases in liver function tests, it is generally considered a preferable agent to methotrexate in patients with liver disease or in patients who have hepatitis B or C.
Iron can bind with sulfasalazine, decreasing sulfasalazine absorption and possibly decreasing iron absorption. This interaction can be minimized by taking iron-containing products two hours before or after sulfasalazine.
Emre Ali Demir
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